Prof. Dr. Dominik Fischer

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Institute for Ophthalmic Research

Centre for Ophthalmology,

University of Tübingen

Elfriede-Aulhorn-Strasse 7

D-72076 Tübingen,

Germany



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Publications


Reichel FF, Dauletbekov DL, Klein R, Peters T, Ochakovski GA, Seitz IP, Wilhelm B, Ueffing M, Biel M, Wissinger B, Michalakis S, Bartz Schmidt KU, Fischer MD (2017) AAV8 can induce innate and adaptive immune response in the primate eye. Mol Ther 25(12): 2648-2660


Ochakovski GA, Peters T, Michalakis S, Wilhelm B, Bartz-Schmidt KU, Fischer MD (2017) Subretinal injection for gene therapy does not cause clinically significant outer nuclear layer thinning in normal primate foveae. Invest Ophthalmol Vis Sci 58(10): 4155-4160


Lisowska J, Lisowski L, Kelbsch C, Maeda F, Richter P, Kohl S, Zobor D, Strasser T, Stingl K, Zrenner E, Peters T, Wilhelm H, Fischer MD, Wilhelm B, Consortium R-C (2017) Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3-Linked Achromatopsia. Invest Ophthalmol Vis Sci 58: 1274-1282 


Hariri AH, Velaga SB, Girach A, Ip MS, Le PV, Lam BL, Fischer MD, Sankila EM, Pennesi ME, Holz FG, MacLaren RE, Birch DG, Hoyng CB, MacDonald IM, Black GC, Tsang SH, Bressler NM, Larsen M, Gorin MB, Webster AR, Sadda SR, Natural History of the Progression of Choroideremia Study G (2017) Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved Retinal Pigment Epithelium Area in Eyes With Choroideremia. Am J Ophthalmol 179: 110-117 


Fischer MD, McClements ME, Martinez-Fernandez de la Camara C, Bellingrath JS, Dauletbekov D, Ramsden SC, Hickey DG, Barnard AR, MacLaren RE (2017) Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa. Mol Ther 25(8):1854-1865


Fischer MD, Hickey DG, Singh MS, MacLaren RE (2016) Evaluation of an Optimized Injection System for Retinal Gene Therapy in Human Patients. Hum Gene Ther Methods 27: 150-158

 

Fischer MD (2016) On Retinal Gene Therapy. Ophthalmologica 236: 1-7


Seitz IP, Zhour A, Kohl S, Llanova P, Peters T, Wilhelm B, Zrenner E, Ueffing M, Bartz Schmidt KU, Fischer MD (2015) Multimodal assessment of choroideremia patients defines pre-treatment characteristics. Graefes Arch Clin Exp Ophthalmol 253(12):2143-50


Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Muhlfriedel R, Trifunovic D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW (2011) A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet 20: 941-947 


Michalakis S, Muhlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Buning H, Paquet-Durand F, Zong X, Gollisch T, Biel M, Seeliger MW (2010) Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Mol Ther 18: 2057-2063

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